Flumazenilum [Latin]
Flumazenilum [Latin] Brand names, Flumazenilum [Latin] Analogs
Flumazenilum [Latin] Brand Names Mixture
- No information avaliable
Flumazenilum [Latin] Chemical_Formula
C32H26N4O2
Flumazenilum [Latin] RX_link
No information avaliable
Flumazenilum [Latin] fda sheet
Flumazenilum [Latin] msds (material safety sheet)
Flumazenilum [Latin] Synthesis Reference
No information avaliable
Flumazenilum [Latin] Molecular Weight
498.575 g/mol
Flumazenilum [Latin] Melting Point
No information avaliable
Flumazenilum [Latin] H2O Solubility
Very slightly soluble (0.15 mg/mL at 23oC)
Flumazenilum [Latin] State
Solid
Flumazenilum [Latin] LogP
5.955
Flumazenilum [Latin] Dosage Forms
Liquid (ampule containing 20 mg conivaptan hydrochloride)
Flumazenilum [Latin] Indication
For the treatment of euvolemic hyponatremia (e.g. the syndrome of inappropriate secretion of antidiuretic hormone, or in the setting of hypothyroidism, adrenal insufficiency, pulmonary disorders, etc.) in hospitalized patients.
Flumazenilum [Latin] Pharmacology
Conivaptan is a nonpeptide, dual antagonist of arginine vasopressin (AVP) V1A and V2 receptors. The level of AVP in circulating blood is critical for the regulation of water and electrolyte balance and is usually elevated in both euvolemic and hypervolemic hyponatremia. The AVP effect is mediated through V2 receptors, which are functionally coupled to aquaporin channels in the apical membrane of the collecting ducts of the kidney. These receptors help to maintain plasma osmolality within the normal range. The predominant pharmacodynamic effect of conivaptan in the treatment of hyponatremia is through its V2 antagonism of AVP in the renal collecting ducts, an effect that results in aquaresis, or excretion of free water. The pharmacodynamic effects of conivaptan include increased free water excretion (i.e., effective water clearance [EWC]) generally accompanied by increased net fluid loss, increased urine output, and decreased urine osmolality.
Flumazenilum [Latin] Absorption
No information avaliable
Flumazenilum [Latin] side effects and Toxicity
Although no data on overdosage in humans are available, conivaptan has been administered as a 20 mg loading dose on Day 1 followed by continuous infusion of 80 mg/day for 4 days in hyponatremia patients and up to 120 mg/day for 2 days in CHF patients. No new toxicities were identified at these higher doses, but adverse events related to the pharmacologic activity of conivaptan, e.g. hypotension and thirst, occurred more frequently at these higher doses.
Flumazenilum [Latin] Patient Information
No information avaliable
Flumazenilum [Latin] Organisms Affected
Humans and other mammals
